These secretagogues are longer-acting; workload is increased on the pancreas for a longer period and can cause beta cell burnout. Also available in combination products.

Product Name
Amaryl sanofi-aventis
DiaBeta sanofi-aventis
DIABINESE Pfizer, Inc.
GLUCOTROL XL Pfizer, Inc.
GLUCOTROL Pfizer, Inc.
Micronase Pfizer, Inc.